APOC3: Triglycerides do matter

APOC3: Triglycerides do matter

INTRODUCTION Obesity, insulin resistance, and metabolic syndrome are escalating problems in developed and developing countries. High plasma triglyceride (TG) levels are commonly encountered in clinical practice; 30% of the adult US population has a TG level above 150mg/dL. Hypertriglyceridemia is perceived to be associated with increased risk of coronary heart disease (CHD) in many epidemiologi...

Loss-of-Function Mutations in APOC3, Triglycerides, and Coronary Disease

Background—Plasma triglyceride levels are heritable and are correlated with the risk of coronary heart disease. Sequencing of the protein-coding regions of the human genome (the exome) has the potential to identify rare mutations that have a large effect on phenotype. Methods—We sequenced the protein-coding regions of 18,666 genes in each of 3734 participants of European or African ancestry in ...

Loss-of-function mutations in APOC3, triglycerides, and coronary disease.

BACKGROUND Plasma triglyceride levels are heritable and are correlated with the risk of coronary heart disease. Sequencing of the protein-coding regions of the human genome (the exome) has the potential to identify rare mutations that have a large effect on phenotype. METHODS We sequenced the protein-coding regions of 18,666 genes in each of 3734 participants of European or African ancestry i...

Dark Chocolate and Metabolic Syndrome; Do Polyphenols All that Matter?

Do Workers\' Remittances Matter for the Egyptian Economy?

Workers’ remittances constitute one of the most important sources of external finance for many developing countries. Although it shows a decreasing trend in recent years, Egypt after 1970s with her regular and massive labor migration to abroad has been still one of the gainer countries on remittances across the world. Empirical studies that implemented for various countries reveal workers’ ...